|
KMID : 0364920160410030206
|
|
Journal of Radiation Protection and Research
2016 Volume.41 No. 3 p.206 ~ p.210
|
|
|
Effects of Wearing Bio-active Material Coated Fabric against γ-irradiation-induced Cellular Damage in Sprague-Dawley Rats
|
|
Kang Jung-Ae
Kim Hye-Rim
Yoon Sun-Hye
Nam You-Ree
Park Sang-Hyun
Go Kyung-Chan
Yang Gwang-Wung
Rho Young-Hwan
Park Hyo-Suk
Jang Beom-Su
|
|
|
Abstract
|
|
|
Background: Ionizing radiation causes cellular damage and death through the direct damage and/or indirectly the production of ROS, which induces oxidative stress. This study was designed to evaluate the in vivo radioprotective effects of a bio-active material coated fabric (BMCF) against γ-irradiation-induced cellular damage in Sprague-Dawley (SD) rats.
Materials and Methods: Healthy male SD rats wore bio-active material coated (concentrations in 10% and 30%) fabric for 7 days after 3 Gy of γ-irradiation. Radioprotective effects were evaluated by performing various biochemical assays including spleen and thymus index, WBC count, hepatic damage marker enzymes [aspartate transaminase (AST) and alanine transaminase (ALT)] in plasma, liver antioxidant enzymes, and mitochondrial activity in muscle.
Results and Discussions: Exposure to γ-irradiation resulted in hepatocellular and immune systemic damage. Gamma-irradiation induced decreases in antioxidant enzymes. However, wearing the BMCF-30% decreased significantly AST and ALT activities in plasma. Furthermore, wearing the BMCF-30% increased SOD (superoxide dismutase) and mitochondrial activity.
Conclusion: These results suggest that wearing BMCF offers effective radioprotection against γ-irradiation-induced cellular damage in SD rats.
|
|
|
KEYWORD
|
|
|
BMCF, γ-irradiation, Cellular damage
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|